Miles between Knoxville, TN and Port St Lucie, FL

There are
754 mi
from Knoxville, TN to Port St Lucie, FL

That's the driving distance. It would take 13 hours 54 mins to go from Knoxville, Tennessee to Port St Lucie, Florida.

The flight distance (direct flight from Knoxville, TN to Port St Lucie, FL) is 635.53 mi.

754 mi = 1,213.68 kms