There are
2,152 mi
from Knoxville, TN to Palmdale, CA
That's the driving distance. It would take 1 day 13 hours to go from Knoxville, Tennessee to Palmdale, California.
The flight distance (direct flight from Knoxville, TN to Palmdale, CA) is 1,921.47 mi.
2,152 mi = 3,462.74 kms