Miles between Knoxville, TN and Orangeburg, SC

There are
301 mi
from Knoxville, TN to Orangeburg, SC

That's the driving distance. It would take 5 hours 47 mins to go from Knoxville, Tennessee to Orangeburg, South Carolina.

The flight distance (direct flight from Knoxville, TN to Orangeburg, SC) is 243.68 mi.

301 mi = 483.91 kms