There are
498 mi
from Knoxville, TN to Mishawaka, IN
That's the driving distance. It would take 9 hours 33 mins to go from Knoxville, Tennessee to Mishawaka, Indiana.
The flight distance (direct flight from Knoxville, TN to Mishawaka, IN) is 411.90 mi.
498 mi = 802.22 kms