There are
529 mi
from Knoxville, TN to Midlothian, IL
That's the driving distance. It would take 9 hours 53 mins to go from Knoxville, Tennessee to Midlothian, Illinois.
The flight distance (direct flight from Knoxville, TN to Midlothian, IL) is 441.46 mi.
529 mi = 851.32 kms