There are
2,423 mi
from Knoxville, TN to Manteca, CA
That's the driving distance. It would take 1 day 18 hours to go from Knoxville, Tennessee to Manteca, California.
The flight distance (direct flight from Knoxville, TN to Manteca, CA) is 2,051.49 mi.
2,423 mi = 3.22 kms