There are
2,326 mi
from Knoxville, TN to Lompoc, CA
That's the driving distance. It would take 1 day 16 hours to go from Knoxville, Tennessee to Lompoc, California.
The flight distance (direct flight from Knoxville, TN to Lompoc, CA) is 2,050.29 mi.
2,326 mi = 3,743.34 kms