There are
1,093 mi
from Knoxville, TN to Lexington, NE
That's the driving distance. It would take 20 hours 8 mins to go from Knoxville, Tennessee to Lexington, Nebraska.
The flight distance (direct flight from Knoxville, TN to Lexington, NE) is 917.64 mi.
1,093 mi = 1.61 kms