There are
2,428 mi
from Knoxville, TN to Lathrop, CA
That's the driving distance. It would take 1 day 18 hours to go from Knoxville, Tennessee to Lathrop, California.
The flight distance (direct flight from Knoxville, TN to Lathrop, CA) is 2,054.54 mi.
2,428 mi = 3,907.14 kms