Miles between Knoxville, TN and Lancaster, SC

There are
254 mi
from Knoxville, TN to Lancaster, SC

That's the driving distance. It would take 5 hours 13 mins to go from Knoxville, Tennessee to Lancaster, South Carolina.

The flight distance (direct flight from Knoxville, TN to Lancaster, SC) is 197.11 mi.

254 mi = 409.42 kms