There are
2,536 mi
from Knoxville, TN to Lake Oswego, OR
That's the driving distance. It would take 1 day 20 hours to go from Knoxville, Tennessee to Lake Oswego, Oregon.
The flight distance (direct flight from Knoxville, TN to Lake Oswego, OR) is 2,109.57 mi.
2,536 mi = 3.22 kms