There are
2,169 mi
from Knoxville, TN to La Puente, CA
That's the driving distance. It would take 1 day 13 hours to go from Knoxville, Tennessee to La Puente, California.
The flight distance (direct flight from Knoxville, TN to La Puente, CA) is 1,921.15 mi.
2,169 mi = 3,491.29 kms