There are
829 mi
from Knoxville, TN to La Crosse, WI
That's the driving distance. It would take 15 hours 31 mins to go from Knoxville, Tennessee to La Crosse, Wisconsin.
The flight distance (direct flight from Knoxville, TN to La Crosse, WI) is 665.78 mi.
829 mi = 1,333.80 kms