There are
246 mi
from Knoxville, TN to Jeffersonville, IN
That's the driving distance. It would take 4 hours 34 mins to go from Knoxville, Tennessee to Jeffersonville, Indiana.
The flight distance (direct flight from Knoxville, TN to Jeffersonville, IN) is 188.79 mi.
246 mi = 396.06 kms