There are
2,181 mi
from Knoxville, TN to Irvine, CA
That's the driving distance. It would take 1 day 13 hours to go from Knoxville, Tennessee to Irvine, California.
The flight distance (direct flight from Knoxville, TN to Irvine, CA) is 1,918.19 mi.
2,181 mi = 3,510.36 kms