There are
495 mi
from Knoxville, TN to Hyattsville, MD
That's the driving distance. It would take 9 hours 14 mins to go from Knoxville, Tennessee to Hyattsville, Maryland.
The flight distance (direct flight from Knoxville, TN to Hyattsville, MD) is 434.77 mi.
495 mi = 796.01 kms