Miles between Knoxville, TN and Florence, SC

There are
340 mi
from Knoxville, TN to Florence, SC

That's the driving distance. It would take 6 hours 35 mins to go from Knoxville, Tennessee to Florence, South Carolina.

The flight distance (direct flight from Knoxville, TN to Florence, SC) is 264.83 mi.

340 mi = 547.59 kms