Miles between Knoxville, TN and Durham, NC

There are
344 mi
from Knoxville, TN to Durham, NC

That's the driving distance. It would take 6 hours 27 mins to go from Knoxville, Tennessee to Durham, North Carolina.

The flight distance (direct flight from Knoxville, TN to Durham, NC) is 280.78 mi.

344 mi = 553.44 kms