Miles between Knoxville, TN and Columbia, SC

There are
263 mi
from Knoxville, TN to Columbia, SC

That's the driving distance. It would take 5 hours 6 mins to go from Knoxville, Tennessee to Columbia, South Carolina.

The flight distance (direct flight from Knoxville, TN to Columbia, SC) is 212.18 mi.

263 mi = 423.45 kms