Miles between Knoxville, TN and Clayton, MO

There are
492 mi
from Knoxville, TN to Clayton, MO

That's the driving distance. It would take 9 hours 3 mins to go from Knoxville, Tennessee to Clayton, Missouri.

The flight distance (direct flight from Knoxville, TN to Clayton, MO) is 397.58 mi.

492 mi = 792.33 kms