There are
2,458 mi
from Knoxville, TN to Clayton, CA
That's the driving distance. It would take 1 day 19 hours to go from Knoxville, Tennessee to Clayton, California.
The flight distance (direct flight from Knoxville, TN to Clayton, CA) is 2,088.97 mi.
2,458 mi = 3,955.42 kms