Miles between Knoxville, TN and Cape Girardeau, MO

There are
383 mi
from Knoxville, TN to Cape Girardeau, MO

That's the driving distance. It would take 7 hours 21 mins to go from Knoxville, Tennessee to Cape Girardeau, Missouri.

The flight distance (direct flight from Knoxville, TN to Cape Girardeau, MO) is 323.92 mi.

383 mi = 616.80 kms