There are
771 mi
from Knoxville, TN to Canandaigua, NY
That's the driving distance. It would take 14 hours 38 mins to go from Knoxville, Tennessee to Canandaigua, New York.
The flight distance (direct flight from Knoxville, TN to Canandaigua, NY) is 595.06 mi.
771 mi = 1,240.64 kms