There are
479 mi
from Knoxville, TN to Amherst, OH
That's the driving distance. It would take 9 hours 21 mins to go from Knoxville, Tennessee to Amherst, Ohio.
The flight distance (direct flight from Knoxville, TN to Amherst, OH) is 386.66 mi.
479 mi = 770.71 kms