There are
2,489 mi
from Knoxville, TN to American Canyon, CA
That's the driving distance. It would take 1 day 19 hours to go from Knoxville, Tennessee to American Canyon, California.
The flight distance (direct flight from Knoxville, TN to American Canyon, CA) is 2,104.24 mi.
2,489 mi = 4,006.36 kms