There are
350 mi
from Kalamazoo, MI to Jeffersonville, IN
That's the driving distance. It would take 6 hours 29 mins to go from Kalamazoo, Michigan to Jeffersonville, Indiana.
The flight distance (direct flight from Kalamazoo, MI to Jeffersonville, IN) is 277.46 mi.
350 mi = 563.30 kms