There are
769 mi
from Kalamazoo, MI to Holyoke, MA
That's the driving distance. It would take 14 hours 41 mins to go from Kalamazoo, Michigan to Holyoke, Massachusetts.
The flight distance (direct flight from Kalamazoo, MI to Holyoke, MA) is 662.80 mi.
769 mi = 1,236.91 kms