There are
395 mi
from Kalamazoo, MI to Edwardsville, IL
That's the driving distance. It would take 7 hours 23 mins to go from Kalamazoo, Michigan to Edwardsville, Illinois.
The flight distance (direct flight from Kalamazoo, MI to Edwardsville, IL) is 332.11 mi.
395 mi = 635.06 kms