There are
350 mi
from Joliet, IL to Cape Girardeau, MO
That's the driving distance. It would take 6 hours 39 mins to go from Joliet, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Joliet, IL to Cape Girardeau, MO) is 301.41 mi.
350 mi = 563.41 kms