There are
2,286 mi
from Johnson City, TN to Irvine, CA
That's the driving distance. It would take 1 day 15 hours to go from Johnson City, Tennessee to Irvine, California.
The flight distance (direct flight from Johnson City, TN to Irvine, CA) is 2,002.99 mi.
2,286 mi = 3,679.19 kms