There are
1,828 mi
from Jackson, MS to Rancho Santa Margarita, CA
That's the driving distance. It would take 1 day 7 hours to go from Jackson, Mississippi to Rancho Santa Margarita, California.
The flight distance (direct flight from Jackson, MS to Rancho Santa Margarita, CA) is 1,587.40 mi.
1,828 mi = 1.61 kms