There are
1,715 mi
from Irvine, CA to West Plains, MO
That's the driving distance. It would take 1 day 5 hours to go from Irvine, California to West Plains, Missouri.
The flight distance (direct flight from Irvine, CA to West Plains, MO) is 1,475.02 mi.
1,715 mi = 2,759.26 kms