There are
1,720 mi
from Irvine, CA to West Plains, MO
That's the driving distance. It would take 1 day 6 hours to go from Irvine, California to West Plains, Missouri.
The flight distance (direct flight from Irvine, CA to West Plains, MO) is 1,475.02 mi.
1,720 mi = 1.61 kms