There are
1,822 mi
from Irvine, CA to Wentzville, MO
That's the driving distance. It would take 1 day 7 hours to go from Irvine, California to Wentzville, Missouri.
The flight distance (direct flight from Irvine, CA to Wentzville, MO) is 1,536.44 mi.
1,822 mi = 1.61 kms