There are
1,824 mi
from Irvine, CA to St Charles, MO
That's the driving distance. It would take 1 day 7 hours to go from Irvine, California to St Charles, Missouri.
The flight distance (direct flight from Irvine, CA to St Charles, MO) is 1,554.61 mi.
1,824 mi = 2,935.36 kms