There are
1,597 mi
from Irvine, CA to South Sioux City, NE
That's the driving distance. It would take 1 day 4 hours to go from Irvine, California to South Sioux City, Nebraska.
The flight distance (direct flight from Irvine, CA to South Sioux City, NE) is 1,306.63 mi.
1,597 mi = 1.61 kms