There are
466 mi
from Irvine, CA to South Lake Tahoe, CA
That's the driving distance. It would take 9 hours 47 mins to go from Irvine, California to South Lake Tahoe, California.
The flight distance (direct flight from Irvine, CA to South Lake Tahoe, CA) is 382.59 mi.
466 mi = 749.76 kms