There are
1,847 mi
from Irvine, CA to Sikeston, MO
That's the driving distance. It would take 1 day 8 hours to go from Irvine, California to Sikeston, Missouri.
The flight distance (direct flight from Irvine, CA to Sikeston, MO) is 1,600.29 mi.
1,847 mi = 1.61 kms