There are
2,617 mi
from Irvine, CA to Rockville, MD
That's the driving distance. It would take 1 day 22 hours to go from Irvine, California to Rockville, Maryland.
The flight distance (direct flight from Irvine, CA to Rockville, MD) is 2,272.11 mi.
2,617 mi = 4,212.38 kms