There are
2,547 mi
from Irvine, CA to Palmetto, FL
That's the driving distance. It would take 1 day 20 hours to go from Irvine, California to Palmetto, Florida.
The flight distance (direct flight from Irvine, CA to Palmetto, FL) is 2,126.87 mi.
2,547 mi = 3.22 kms