There are
2,464 mi
from Irvine, CA to North Charleston, SC
That's the driving distance. It would take 1 day 19 hours to go from Irvine, California to North Charleston, South Carolina.
The flight distance (direct flight from Irvine, CA to North Charleston, SC) is 2,173.26 mi.
2,464 mi = 3,965.29 kms