There are
2,391 mi
from Irvine, CA to Niles, OH
That's the driving distance. It would take 1 day 18 hours to go from Irvine, California to Niles, Ohio.
The flight distance (direct flight from Irvine, CA to Niles, OH) is 2,079.75 mi.
2,391 mi = 3,847.90 kms