There are
1,440 mi
from Irvine, CA to Mesquite, TX
That's the driving distance. It would take 1 day to go from Irvine, California to Mesquite, Texas.
The flight distance (direct flight from Irvine, CA to Mesquite, TX) is 1,224.57 mi.
1,440 mi = 1.61 kms