There are
2,507 mi
from Irvine, CA to Mebane, NC
That's the driving distance. It would take 1 day 20 hours to go from Irvine, California to Mebane, North Carolina.
The flight distance (direct flight from Irvine, CA to Mebane, NC) is 2,175.67 mi.
2,507 mi = 3.22 kms