There are
2,357 mi
from Irvine, CA to Mayfield Heights, OH
That's the driving distance. It would take 1 day 17 hours to go from Irvine, California to Mayfield Heights, Ohio.
The flight distance (direct flight from Irvine, CA to Mayfield Heights, OH) is 2,045.02 mi.
2,357 mi = 3.22 kms