There are
2,182 mi
from Irvine, CA to Maryville, TN
That's the driving distance. It would take 1 day 14 hours to go from Irvine, California to Maryville, Tennessee.
The flight distance (direct flight from Irvine, CA to Maryville, TN) is 1,916.77 mi.
2,182 mi = 3,511.89 kms