There are
1,619 mi
from Irvine, CA to Maryville, MO
That's the driving distance. It would take 1 day 4 hours to go from Irvine, California to Maryville, Missouri.
The flight distance (direct flight from Irvine, CA to Maryville, MO) is 1,341.07 mi.
1,619 mi = 1.61 kms