There are
1,991 mi
from Irvine, CA to Madisonville, KY
That's the driving distance. It would take 1 day 11 hours to go from Irvine, California to Madisonville, Kentucky.
The flight distance (direct flight from Irvine, CA to Madisonville, KY) is 1,715.07 mi.
1,991 mi = 1.61 kms