There are
1,826 mi
from Irvine, CA to Lake St Louis, MO
That's the driving distance. It would take 1 day 7 hours to go from Irvine, California to Lake St Louis, Missouri.
The flight distance (direct flight from Irvine, CA to Lake St Louis, MO) is 1,539.72 mi.
1,826 mi = 1.61 kms