There are
2,180 mi
from Irvine, CA to Knoxville, TN
That's the driving distance. It would take 1 day 13 hours to go from Irvine, California to Knoxville, Tennessee.
The flight distance (direct flight from Irvine, CA to Knoxville, TN) is 1,918.19 mi.
2,180 mi = 3,508.59 kms