There are
2,679 mi
from Irvine, CA to Hyattsville, MD
That's the driving distance. It would take 1 day 23 hours to go from Irvine, California to Hyattsville, Maryland.
The flight distance (direct flight from Irvine, CA to Hyattsville, MD) is 2,283.77 mi.
2,679 mi = 3.22 kms